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KMID : 0606920230310040359
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Biomolecules & Therapeutics
2023 Volume.31 No. 4 p.359 ~ p.369
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Caspase Cleavage of Receptor Tyrosine Kinases in the Dependence Receptor Family
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Park Gyu-Hwan
Kang Yoo-Kyung
Paek Seung-Mann
Shin Chan-Young
Han Sun-Young
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Abstract
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Dependence receptors are a group of receptor proteins with shared characteristics of transducing two different signals within cells. They can transduce a positive signal of survival and differentiation in the presence of ligands. On the other hand, dependence receptors can transduce an apoptosis signal in the absence of ligands. The function of these receptors depends on the availability of their ligands. Several receptor tyrosine kinases (RTKs) have been reported as dependence receptors. When cells undergo apoptosis by dependence receptors, the intracellular domain of some RTKs is cleaved by the caspases. Among the RTKs that belong to dependence receptors, we focused on eight RTKs (RET, HER2, MET, ALK, TrkC, EphA4, EphB3, and c-KIT) that are cleaved by caspases. In this review, we describe the features of the receptors, their cleavage sites, and the fate of the cleaved products, as well as recent implications on them being used as potential therapeutics for cancer treatment.
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KEYWORD
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Dependence receptor, Cleavage, Receptor tyrosine kinase, Caspase
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